diff --git a/README.md b/README.md index b719667..f1ca4e5 100644 --- a/README.md +++ b/README.md @@ -19,11 +19,17 @@ Here are the main steps which will allow you to build a precise model for CPP design: **1. Data curation and cleaning.** All inappropriate or ambiguous data should be removed or corrected. + **2. Data unification.** The data presented in Datasets are heterogeneous and should be unified in terms of variables, measurement units etc. + **3. System parametriation.** You need to choose the set of parameters to describe CPPs as well as experimental setup. Most of the models use symbolic representations lacking physico-chemical properties crucial for CPP activity prediction. + **4. Model selection.** Best-performing models should be choosen for screening depending on the task complexity (sequence classification or sequence generation). + **5. Feature selecction.** After model selection, features used in the model should be choosen showing optimal prediction performance, robustness, and interpretability. + **6. Evaluation.** Every model should be evaluated beyond performance on train/test datasets. It can be structural analysis of CPP candidates, modelling of interaction with cellular membranes etc. + **7. Project design.** All results should be structured and systematized on GitHub for transparency and reproducibility. ### Challenges